服部素之

发布时间:2021-06-27浏览次数:5244

教师基本信息

姓名:服部素之/ Motoyuki HATTORI

职称:研究员/Professor

职务:研究员/Professor

电子邮箱:hattorim@fudan.edu.cn

办公地点:上海市杨浦区淞沪路2005号必赢bwin线路检测网站A201


研究方向

离子通道以及转运体的结构与功能,膜蛋白的表达鉴定技术研发


个人简介

教育工作经历

2005年获得日本东京大学生物化学学士学位,2009年获得日本东京工业大学生命信息博士学位。2009-2012年在美国俄勒冈健康与科学大学从事博士后研究,2012-2015年在日本东京大学生物化学系任助理研究员及JST研究员。

科研项目

国家自然科学基金面上项目和外青项目、外国优秀青年项目、科技部重点研发计划青年科学家专题等。



授课情况

现代生物化学和结构生物学训练课程,结构生物学课程


招生专业

生理和生物物理/Physiology and Biophysics


代表性论文和论著:

1. Sheng D, Yue C, Jin F, Wang Y, Ichikawa M, Yu Y, Guo CR*, Hattori M*. Structural insights into the orthosteric inhibition of P2X receptors by non-ATP-analog antagonists. eLife. 2023, 12:RP92829. *Corresponding authors.


2. Shen C, Zhang Y, Cui W, Zhao Y, Sheng D, Teng X, Shao M, Ichikawa M, Wang J*, Hattori M*. Structural insights into the allosteric inhibition of P2X4 receptors. Nat Commun. 2023, 14(1):6437. 


3. Sumino A*, Zhao Y, Mukai D, Sumikama T, Puppulin L, Hattori M*, Shibata M. Antithetic effects of agonists and antagonists on the structural fluctuations of TRPV1 channel. Proc Natl Acad Sci U S A. 2023, 120(20):e2301013120. 


4. Jin F, Sun M, Fujii T, Yamada Y, Wang J, Maturana AD, Wada M, Su S, Ma J, Takeda H, Kusakizako T, Tomita A, Nakada-Nakura Y, Liu K, Uemura T, Nomura Y, Nomura N, Ito K, Nureki O, Namba K, Iwata S, Yu Y, Hattori M*. The structure of MgtE in the absence of magnesium provides new insights into channel gating. PLoS Biol. 2021, 19(4):e3001231. 


5. Huang Y, Jin F, Funato Y, Xu Z, Zhu W, Wang J, Sun M, Zhao Y, Yu Y, Miki H*, Hattori M*. Structural basis for the Mg2+ recognition and regulation of the CorC Mg2+ transporter. Sci Adv. 2021, 7(7):eabe6140. 


6. Jia Y, Zhao Y, Kusakizako T, Wang Y, Pan C, Zhang Y, Nureki O*, Hattori M*, Yan Z*. TMC1 and TMC2 Proteins Are Pore-Forming Subunits of Mechanosensitive Ion Channels. Neuron. 2020, 105(2):310-321. 


7. Li M, Wang Y, Banerjee R, Marinelli F, Silberberg S, Faraldo-Gomez J*, Hattori M*, Swartz K*. Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP. eLife. 2019, 8:e47060. 


8. Wang J, Wang Y, Cui WW, Huang Y, Yang Y, Liu Y, Zhao WS, Cheng XY, Sun WS, Cao P, Zhu MX, Wang R*, Hattori M*, Yu Y*. Druggable negative allosteric site of P2X3 receptors. Proc Natl Acad Sci U S A. 2018, 115(19):4939-4944.